Press releases

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Cyxone's development substance T20K's capacity to prevent and inhibit multiple sclerosis in animal models now verified by independent study

Cyxone can announce today that an independent research group at Monash University in Australia has confirmed the positive effects of the company's development substance T20K on multiple sclerosis (MS) symptoms in animal models as previously described.

Cyxone's development programme includes the confirmation of the positive results achieved with T20K on MS in animal models that a research group at the Medical University of Vienna outlined in an article published in March 2016 in the respected PNAS scientific journal and elsewhere. It is standard procedure ahead of clinical trials to allow independent laboratories to confirm the effectiveness of a new drug that is intended to be developed into a competitive product.

The research group investigated whether T20K, through pre-treatment of animals with a single dose administered seven days before initiation of the disease, could prevent the animals from developing MS symptoms, and that daily treatment with T20K after initiation, could prevent the development of MS.

The study showed that only one dose of either 5 or 10 mg/kg of T20K seven days prior to the initiation of the disease significantly delayed the development of symptoms, reduced the extent of MS symptoms, and significantly reduced the overall development of the illness in the animals.

When the test animals were started on an oral treatment of T20K at the same time as the disease was initiated, T20K delayed and reduced the development of symptoms even at 1mg/kg/day. With a dose of 3mg/kg/day, the animals displayed no measurable MS symptoms. The positive control substance Fingolimod (Gilenya) applied at the same 3mg/kg/day dose, showed similar effects on MS symptoms as T20K.

The results from Monash University thereby confirm that T20K has both the capacity to prevent MS, and to treat existing MS. The new study also shows that T20K works at considerably lower doses than previously described. Complete inhibition of MS symptoms takes place with an oral dose of 3mg/kg/day, compared to the previous effective oral dose of 20mg/kg/day.

The results suggest that T20K has a very competitive effect on MS compared to today's leading MS product, Gilenya; and that the safety interval appears to be even greater than previously achieved.

Cyxone's CEO, Kjell Stenberg, says: "Although we never doubted the findings of the research group at the Medical University of Vienna, we're delighted that it's been demonstrated that T20K performs even better against MS in animal models than we had previously thought, which provides encouragement for our work in studying T20K's effects on humans." Cyxone's chairman, Bert Junno, says: "The new results from the Australian laboratory strengthens Cyxone's leading position in the development of safer more effective MS treatments."

March 10, 2017

Contact
Cyxone AB (publ.)
Kjell G. Stenberg, CEO
Tel: +46 (0) 723 816 168
Email: kjell.g.stenberg@cyxone.com
Adelgatan 21
211 22 Malmö
www.cyxone.com

This is information that Cyxone AB is required to publish under the EU Market Abuse Directive. The information was provided under the auspices of the above contact person for publication on March 10, 2017 at 13:00 CET.

About Cyxone
Cyxone AB (publ.) is a biopharmaceutical company that develops drugs based on cyclotides, a class of natural plant protein. Cyclotide technology has the potential to provide new drugs with beneficial pharmacological effects on diseases that currently lack safe and effective treatments. The company is focusing on the development of T20K, a substance that inhibits key processes in cells that are typically associated with various immune disorders, such as multiple sclerosis and rheumatoid arthritis. Cyxone's Certified Adviser on the Nasdaq First North is Erik Penser Bank.

August 30, 2017
Regulatory

Summary of interim report

Period (2017-01-01-2017-06-30)

  • Operating revenue KSEK 0 (0)
  • Income after financial items KSEK -4 075 (-1 626)
  • Earnings per share -0,27 (-0,13) SEK
  • Cash and cash equivalents, KSEK 28 114 (24 636) as of 2017-06-30
  • Equity ratio 95,2 (87,9) % as of 2017-06-30

Period (2017-04-01-2017-06-30)

  • Operating revenue KSEK 0 (0)
  • Income after financial items KSEK -2 588 (-1 157)
  • Earnings per share SEK -0,17 (-0,09) 
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June 14, 2017

Cyxone signs acquisition agreement for candidate drug in Phase 2 Cyxone can announce today that the company has signed an agreement pertaining to the exclusive rights to acquire the clinical candidate drug Rabeximod from OxyPharma AB. The transaction has been structured so as to minimise the impact on Cyxone's cash flow by offering the seller 1,916,372 shares, (one million, nine hundred and sixteen thousand, three hundred and seventy two shares amounting to a dilution of 12.5 per cent), as well as royalty rights amounting to ten (10) per cent of future net earnings from Rabeximod. Cyxone will call an extraordinary general meeting to seek shareholder approval for a directed new share issue. This will pave the way for the acquisition and a Phase 2b-study in rheumatoid arthritis.

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June 07, 2017

Cyxone AB and the University of Queensland in Australia are launching a co- operation agreement to continue studies into the effects of Cyxone's T20K development substance in combating MS.

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May 18, 2017

Cyxone can announce today that it has established a long-term strategic co-operation agreement with Sourcia, a clinical contract research organization (CRO) with offices in Belgium, Germany, and the Netherlands.

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May 16, 2017
Regulatory

Period (2017-01-01-2017-03-31)

  • Operating revenue KSEK 0 (0)
  • Income after financial items KSEK -1491 (-307)
  • Earnings per share -0,10 (-0,04) SEK
  • Cash and cash equivalents (2017-03-31) 31 275 (4 114) KSEK
  • Equity ratio 98,2 (97,8) % as of 2017-03-31
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May 15, 2017

Since 2016, Cyxone AB and Swiss pharmaceutical manufacturer Bachem AG have worked closely on the production of syntheses of Cyxone's development substance T20K, and on the production of substances for studies that started last year.

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March 10, 2017
Regulatory

Cyxone can announce today that an independent research group at Monash University in Australia has confirmed the positive effects of the company's development substance T20K on multiple sclerosis (MS) symptoms in animal models as previously described.

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December 21, 2016
Regulatory

Today, Cyxone announce that they will acquire the entire family of patents protecting the Company's main candidate T20K, from the Medical University of Vienna. The cost of € 100,930 includes VAT and corresponds to the costs of the patenting process.

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December 19, 2016
Regulatory

Cyxone announce that T20K demonstrates no measurable toxic effect in mice after oral administration of up to 100 mg/kg in a single dose.  Even at an oral dose of 250 mg/kg, half of the animals recovered well after treatment. Low toxicity of injected T20K has previously been reported by Cyxone.

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November 21, 2016
Regulatory

In accordance with the regulations on Nasdaq First North Stockholm, Cyxone uses a Certified Adviser (CA).

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